miniLC Webinar – Prof. Jim Grinias of Rowan University
Speaker: Prof. Jim Grinias of Rowan University
Bio: James Grinias is currently an Associate Professor in the Department of Chemistry & Biochemistry at Rowan University in Glassboro, NJ. His research interests include improving the throughput and efficiency of chromatographic separations and the miniaturization of chemical measurement techniques. He received his Ph.D. from the University of North Carolina at Chapel Hill in 2014 and the moved onto a postdoctoral fellowship at the University of Michigan until the end of 2016. James has received a number of awards for his work to date, including the HPLC 2013 Csaba Horváth Award, the 2020 Young Investigator Award from the Chinese American Chromatography Association, a National Science Foundation CAREER grant, the 2021 American Chemical Society Satinder Ahuja Young Investigator in Separation Science Award, and the 2022 LCGC Emerging Leader in Chromatography Award. He was also named to The Analytical Scientist’s “Top 40 Under 40” Power List in 2018. To date, he has published over 30 articles and given over 80 oral/poster presentations.
Topic: Utilizing Compact, Integrated Chromatographic Instrumentation for Pharmaceutical Analysis
Summary: In the realm of quality assurance and quality control within the pharmaceutical industry, reliable and robust analytical methodology is of utmost importance. Many pharmaceutical analysis techniques rely upon chemical separations, especially the use of LC-UV for drug substance and impurity assays. In this presentation, considerations for method development, method validation, and system suitability will be explored in the context of small molecule pharmaceutical analysis, especially common over-the-counter analgesic compounds with published pharmacopeial monograph methods. Considerations for acceptable changes that can be made to methods within pharmacopeial guidelines will also be discussed, including potential advantages and disadvantages that may be observed for various changes. Finally, multiple examples of analgesic drug analysis performed using the new miniLC platform will be demonstrated.
Original Air Date: April 6, 2022 @ 11am EDT